A DNA chip consists of a few hundred to ten thousand types of DNA fragments which are densely placed on a glass or resin substrate. Nucleic acid targets such as DNA and RNA extracted from a sample are hybridized onto the DNA chip. A variety of analyses on DNA and RNA can be performed including determination of base sequences of the targets, analysis of gene mutations, measurements of gene expression levels and copy numbers, and analysis of methylation states.
“Toshiba has been developing the original electrochemical DNA chip. In contrast to the conventional fluorescent DNA chip, labeling of DNA is unnecessary and the detection unit is simple in the electrochemical DNA chip” said Dr. Nobuhiro Gemma, Chief Fellow at Toshiba R&D Center in Tokyo. Toshiba have performed R&D on several DNA chip products such as DNA chip for HPV genotyping, DNA chip system for biological agents and DNA chip for hygienic control. In addition, we introduce a novel DNA chip card system in which DNA amplification is performed on chip and the operation can be performed automatically”.
Dr. Nobuhiro was accompanied by Mr. Jun Okada, Chief Specialist and Mr. Ryuji Nakajima, Specialist at DNA Chip Business Product Division. Mr. Okada gave a presentation on “Next Generation DNA Chip”.
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