{"id":31281,"date":"2025-10-14T03:43:18","date_gmt":"2025-10-13T20:43:18","guid":{"rendered":"https:\/\/www.nanotec.or.th\/en\/?page_id=31281"},"modified":"2025-10-14T05:07:38","modified_gmt":"2025-10-13T22:07:38","slug":"nsb","status":"publish","type":"page","link":"https:\/\/nanotec.or.th\/en\/research-group\/ansi\/nsb\/","title":{"rendered":"NSB"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"31281\" class=\"elementor elementor-31281\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-54ba439 e-con-full e-flex e-con e-parent\" data-id=\"54ba439\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18d9089 elementor-widget elementor-widget-image\" data-id=\"18d9089\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2000\" height=\"774\" src=\"https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH.jpg\" class=\"attachment-full size-full wp-image-31720\" alt=\"\" srcset=\"https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH.jpg 2000w, https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH-300x116.jpg 300w, https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH-1024x396.jpg 1024w, https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH-768x297.jpg 768w, https:\/\/nanotec.or.th\/en\/wp-content\/uploads\/2025\/10\/4.-NSB-TH-1536x594.jpg 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9946428 e-flex e-con-boxed e-con e-parent\" data-id=\"9946428\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b449949 e-flex e-con-boxed e-con e-child\" data-id=\"b449949\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7eaedca elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7eaedca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-flask\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M437.2 403.5L320 215V64h8c13.3 0 24-10.7 24-24V24c0-13.3-10.7-24-24-24H120c-13.3 0-24 10.7-24 24v16c0 13.3 10.7 24 24 24h8v151L10.8 403.5C-18.5 450.6 15.3 512 70.9 512h306.2c55.7 0 89.4-61.5 60.1-108.5zM137.9 320l48.2-77.6c3.7-5.2 5.8-11.6 5.8-18.4V64h64v160c0 6.9 2.2 13.2 5.8 18.4l48.2 77.6h-172z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">nsb<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56bc8d3 elementor-widget elementor-widget-heading\" data-id=\"56bc8d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Nano Safety and Bioactivity<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c85b0fe e-flex e-con-boxed e-con e-child\" data-id=\"c85b0fe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-944a946 elementor-widget elementor-widget-text-editor\" data-id=\"944a946\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The Nano Safety and Bioactivity (NSB) Research Team is at the forefront of research and development in predictive models and testing methods tailored to environmental and health safety evaluations, bioactivity assessments, and efficacy studies. Through our innovative approaches and cutting-edge technology, we support both research institutes and industries across Thailand.<\/p><p>Our expertise spans a range of model systems, including in vitro cell culture with 2D and 3D models that mimic digestive, vascular, skin, and respiratory organs; ex vivo human skin models; and in vivo zebrafish models. These tools enable us to provide comprehensive testing solutions for a wide array of applications.<\/p><p>We provide testing services and work closely with research institutes, companies, and regulatory bodies, playing a significant role in supporting the development of regulatory frameworks and industry standards in Thailand. Our work supports sectors such as nanotechnology, cosmeceuticals, nutraceuticals, food and feed industries, and health and medicine, helping to advance safer, more effective products and innovations in these fields.<\/p><p><strong>Research Scope<\/strong><\/p><ol><li><strong>Development of Models and Testing Methods<\/strong><\/li><\/ol><p>The research team focuses on developing diverse study models, including in vitro, in vivo, and ex vivo, to support academic research and studies relevant to various industries. Additionally, comprehensive testing methods are developed to evaluate the safety and efficacy of substances or products, ensuring high standards for both research and testing services.<\/p><ol start=\"2\"><li><strong>Services and Custom Research Projects<\/strong><\/li><\/ol><p>The team provides testing services and contract research projects, utilizing models developed in-house alongside testing methods that comply with OECD Test Guidelines and proprietary methods created by the team. These offerings are tailored to meet the specific needs of clients and research collaborators.<\/p><ol start=\"3\"><li><strong>Development of Nanoparticles<\/strong><\/li><\/ol><p>Research and development focus on organic nanoparticles and inorganic nanoparticles for applications in various fields such as medicine, cosmetics, and environmental studies. The goal is to produce innovative products with unique properties and high potential for diverse uses.<\/p><ol start=\"4\"><li><strong>Development of Cultured Meat Production Platforms<\/strong><\/li><\/ol><p>The team conducts research and development of cultured meat by integrating 3D printing technology with stem cell sources from economically significant animals. This initiative aims to create a sustainable production process that aligns with the growing demand for alternative protein sources.<\/p><ol start=\"5\"><li><strong>Development of Zebrafish Testing Laboratories to Meet International Standards<\/strong><\/li><\/ol><p>Efforts are focused on enhancing zebrafish testing laboratory to achieve OECD GLP (Good Laboratory Practice) certification. The objective is to elevate research standards and enhance the competitiveness of Thai industries at the international level.<\/p><p>\u00a0<\/p><p><strong>Selected publications<\/strong><\/p><ul><li>Chanajon P, Hamzeh A, Tian F, Roytrakul S, Oluwagunwa OA, Kadam D, Aluko RE, Aueviriyavit S, Wongwanakul R, Yongsawatdigul J. Hypotensive effect of potent angiotensin-I-converting enzyme inhibitory peptides from corn gluten meal hydrolysate: Gastrointestinal digestion and transepithelial transportation modifications. Food Chem. <strong>2025<\/strong> Jan 1;462:140953. <a href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2024.140953\">https:\/\/doi.org\/10.1016\/j.foodchem.2024.140953<\/a><\/li><li>Klinngam W, Rungkamoltip P, Wongwanakul R, Joothamongkhon J, Du-A-Man S, Khongkow M, Asawapirom U, Iempridee T, Ruktanonchai U. Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial. Biomolecules. <strong>2024<\/strong> Jun 29;14(7):776. <a href=\"https:\/\/doi.org\/10.3390\/biom14070776\">https:\/\/doi.org\/10.3390\/biom14070776<\/a><\/li><li>Dechbumroong P, Hu R, Keaswejjareansuk W, Namdee K, Liang XJ. Recent advanced lipid-based nanomedicines for overcoming cancer resistance. Cancer Drug Resist. <strong>2024<\/strong> Jun 21;7:24. <a href=\"https:\/\/doi.org\/10.20517\/cdr.2024\">https:\/\/doi.org\/10.20517\/cdr.2024<\/a><\/li><li>Lapmanee S, Bhubhanil S, Wongchitrat P, Charoenphon N, Inchan A, Ngernsutivorakul T, Dechbumroong P, Khongkow M, Namdee K. Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson&#8217;s Rats. Pharmaceutics.<strong> 2024<\/strong> Apr 8;16(4):514. <a href=\"https:\/\/doi.org\/10.3390\/pharmaceutics16040514\">https:\/\/doi.org\/10.3390\/pharmaceutics16040514<\/a><\/li><li>Malila Y, Charoensuk D, Srimarut Y, Saensa-Ard S, Petpiroon N, Kunyanee C, Rattanawongsa W, Saenmuangchin R, Klamchuen A, Kangwansupamonkon W, Aueviriyavit S. Muscle Proteins, Technological Properties, and Free Amino Acids of Epaxial Muscle Collected from Asian Seabass (Lates calcarifer) at Different Postmortem Durations. Animals (Basel). <strong>2024 <\/strong>Oct 1;14(19):2837. <a href=\"https:\/\/doi.org\/10.3390\/ani14192837\">https:\/\/doi.org\/10.3390\/ani14192837<\/a><\/li><li>Rittidach T, Sillapaprayoon S, Chantho V, Pimtong W, Charoenphandhu N, Thongbunchoo J, Krishnamra N, Bootchanont A, Porjai P, Pon-On W. Investigation on the physical properties and biocompatibility of zirconia-alumina-silicate@diopside composite materials and its <em>in vivo<\/em> toxicity study in embryonic zebrafish. RSC Adv. <strong>2023<\/strong> Oct 18;13(44):30575-30585. <a href=\"https:\/\/doi.org\/10.1039\/d3ra04555b\">https:\/\/doi.org\/10.1039\/d3ra04555b<\/a><\/li><li>Petpiroon N, Netkueakul W, Sukrak K, Wang C, Liang Y, Wang M, Liu Y, Li Q, Kamran R, Naruse K, Aueviriyavit S, Takahashi K. Development of lung tissue models and their applications. Life Sci. <strong>2023<\/strong> Dec 1;334:122208. <a href=\"https:\/\/doi.org\/10.1016\/j.lfs.2023.122208\">https:\/\/doi.org\/10.1016\/j.lfs.2023.122208<\/a><\/li><li>Wongwanakul R, Aueviriyavit S, Furihata T, Gonil P, Sajomsang W, Maniratanachote R, Jianmongkol S. Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model. Sci Rep. <strong>2023 <\/strong>May 16;13(1):7904. <a href=\"https:\/\/doi.org\/10.1038\/s41598-023-34888-0\">https:\/\/doi.org\/10.1038\/s41598-023-34888-0<\/a><\/li><li>Netkueakul W, Chortarea S, Kulthong K, Li H, Qiu G, Jovic M, Gaan S, Hannig Y, Buerki-Thurnherr T, Wick P, Wang J. Airborne emissions from combustion of graphene nanoplatelet\/epoxy composites and their cytotoxicity on lung cells via air-liquid interface cell exposure in vitro. NanoImpact. <strong>2022<\/strong> Jul;27:100414. <a href=\"https:\/\/doi.org\/10.1016\/j.impact.2022.100414\">https:\/\/doi.org\/10.1016\/j.impact.2022.100414<\/a><\/li><li>Kitipaspallop W, Sillapaprayoon S, Phuwapraisirisan P, Kim WK, Chanchao C, Pimtong W. Developmental effects of sesamolin on zebrafish (<em>Danio rerio<\/em>) embryos. Comp Biochem Physiol C Toxicol Pharmacol. <strong>2022<\/strong> Jun;256:109319. <a href=\"https:\/\/doi.org\/10.1016\/j.cbpc.2022.109319\">https:\/\/doi.org\/10.1016\/j.cbpc.2022.109319<\/a><\/li><li>Petpiroon N, Rosena A, Pimtong W, Charoenlappanit S, Koobkokkruad T, Roytrakul S, Aueviriyavit S. Protective effects of Thai silk sericins and their related mechanisms on UVA-induced phototoxicity and melanogenesis: Investigation in primary melanocyte cells using a proteomic approach. Int J Biol Macromol. <strong>2022<\/strong> Mar 15;201:75-84. <a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.12.061\">https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.12.061<\/a><\/li><li>Klinngam W, Rungkamoltip P, Thongin S, Joothamongkhon J, Khumkhrong P, Khongkow M, Namdee K, Tepaamorndech S, Chaikul P, Kanlayavattanakul M, Lourith N, Piboonprai K, Ruktanonchai U, Asawapirom U, Iempridee T. Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin. Biomed Pharmacother. <strong>2022<\/strong> Jan;145:112461. <a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2021.112461\">https:\/\/doi.org\/10.1016\/j.biopha.2021.112461<\/a><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc97fcd e-flex e-con-boxed e-con e-parent\" data-id=\"cc97fcd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-99f4ec6 e-flex e-con-boxed e-con e-child\" data-id=\"99f4ec6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8c1a1db e-con-full e-flex e-con e-child\" data-id=\"8c1a1db\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-52f6228 elementor-widget elementor-widget-text-editor\" data-id=\"52f6228\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ol><li><p><strong>\u00a0Current Research Projects<\/strong><\/p><ol><li>Skin Rejuvenation Efficacy Testing of Anti-Aging Products on Human Skin Damaged by Exposome<\/li><li>Development of cultured meat production platform<\/li><li>ST68 Enhancing the Zebrafish Testing Laboratory with OECD GLP Standards to Foster Competitiveness in Thailand Cosmetic, Medical, Healthcare, Agricultural, and Food Industries<\/li><li>Development of efficacy and safety testing for national active ingredients and related products to support beauty and wellness industry<\/li><li>Development of an active targeting cannabidiol lipid-nanoparticle (CBD-LNP) prepared by microfluidic reactor as potential therapeutics for Alzheimer\u2019s diseases<\/li><li>Advancing Protocols for Toxicity Testing using Zebrafish Models For Supporting Food and Drug Industries<\/li><li>Empowering Safety and Efficacy Testing Service of Health Product using Cell and Tissue-Based Models<\/li><li>Development of testing platforms for reverse aging based on epigenetic aging clocks and telomere length measurements for longevity cosmeceuticals and nutraceuticals in human skin models<\/li><li>Investigation the Safety and Potential Inhibition of Advanced Glycation End Products Formation by Trikatu Remedy for Nutraceutical Development in Alzheimer Disease<\/li><li>Physicochemical properties and health effects of fine and ultrafine fraction of diesel exhaust particles derived from the combustion of EURO4 and EURO5 diesel vehicles powered by biodiesel fuels (B7, B10, and B20) from palm oil<\/li><li>Efficacy Testing of a Hangover-Combatting Product: Protective Effects on Liver Cell Toxicity and Enhancement of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Activity<\/li><li>Development of safety and efficacy testing for screening biological active compounds from cosmeceuticals and food supplement products in the prevention and treatment of non-communicable diseases (NCDs), anti-aging against air pollutants and newly emerging disease<\/li><li>Improving the quality of quercetin-inulin nanoparticles to enhance the absorption of EGCG and resveratrol using in vitro intestinal model<\/li><li>Development of safety and efficacy testing methods in zebrafish model for the biomedical and pharmaceutical industries<\/li><li>Antibacterial and anti-inflammatory activities testing of herb extracts and herbal toothpaste SIKKHADEE Ten Plus<\/li><li>Development of integrated platform for study of human health and environment impact of micro\/nanoplastics: human 3D-tissue model, simulated gut model and zebrafish model<\/li><li>Training Workshop on Setting-up a Gut-on-Chip Testing System for Animal Feed Industry<\/li><\/ol><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e517d8 e-flex e-con-boxed e-con e-child\" data-id=\"1e517d8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-782db46 e-con-full e-flex e-con e-child\" data-id=\"782db46\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31751ea elementor-widget elementor-widget-text-editor\" data-id=\"31751ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">Contact Us<br \/>Dr. Wittaya Pimthong<br \/>Email : &#119;&#x69;&#116;&#x74;a&#x79;a&#46;&#x70;&#105;&#x6d;&#116;&#x6f;n&#x67;&#64;&#110;&#x61;&#110;&#x6f;t&#x65;c&#x2e;&#x6f;&#114;&#x2e;&#116;&#x68; Tel : 025647100 \u0e15\u0e48\u0e2d 6684<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>nsb Nano Safety and Bioactivity The Nano Safety and Bioactivity (NSB) Research Team is at the forefront of research and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":27084,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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